Drinking a little wine three days after the first shot of rabies vaccine has an effect on the effect of the vaccine and induce or aggravate the adverse reaction of the vaccine. Generally in the first shot of rabies vaccine within a week is to avoid drinking alcohol, alcohol may interfere with the body’s immune response, so that the injection of the vaccine produced by the antibody potency is insufficient, affecting the protective effect of the vaccine, thus failing to achieve the purpose of preventing rabies. Once rabies occurs, there is no effective treatment. Therefore, patients should abstain from alcohol for one week after the first injection of rabies vaccine. Moreover, alcohol may induce or aggravate the adverse reaction of the vaccine, leading to clinical manifestations such as dizziness, nausea, vomiting, fever, rash, etc., which will bring serious adverse consequences to the patients. Drinking alcohol three days after the first shot of rabies vaccine is recommended to go to the hospital and consult a professional doctor whether you need to make up the vaccine.