Tongue hypertrophy should be alert to tongue vascular malformation, tongue hemangioma, angioedema, tongue tissue infection and other diseases. 1. Tongue vascular malformation: there are common tongue venous malformation, micro venous malformation, lymphatic malformation, and patients will have tongue hypertrophy. 2. Tongue hemangioma: there are vascular endothelial cells in the hemangioma with angiogenic phenomenon and mast cell aggregation. 3. Angioedema: allergens lead to dilation of small blood vessels and increased permeability of tongue tissue, resulting in limited edema of tongue tissue, and thus tongue hypertrophy. 4. Infection of tongue tissue: under the stimulation of inflammatory factors, it will cause edema of tongue tissue and hypertrophy of tongue. There are many diseases that cause tongue hypertrophy, it is recommended to go to the hospital in time to find out the cause and treat it in time.