Omicron is a variant of the 2019 new coronavirus, and the probability of secondary infection of Omicron has no clear research data in China, but there is already some data from abroad indicating a higher probability of secondary infection. According to the official statistics of the British government, since the beginning of 2022, the number of secondary infections of Omicron virus in England has surged, and as of May 11, 2022, the proportion of secondary infections has reached 16.6%. The above data indicates a higher probability of secondary infection with Omicron Virus. The best way to target the prevention of secondary infection is to receive the New Crown vaccine, which can greatly reduce the rate of infection and mortality, while daily protection must be taken. Patients should receive the New Crown vaccine in a timely manner, do a good job of daily protection, and at the same time maintain a good state of mind, which is conducive to enhancing the body’s ability to prevent disease, thereby reducing the risk of secondary infection.