High amylase requires attention to the presence of pancreatic or non-pancreatic disease. Blood amylase is primarily derived from the pancreas and parotid gland, with small amounts also secreted from the proximal duodenum, lungs, uterus, and mammary glands during lactation. Circulating blood amylase is excreted by the kidneys as urinary amylase. The following etiologic factors should be considered when amylase is elevated in the clinical setting: 1. Pancreatic diseases: acute pancreatitis is the most common cause of amylase elevation, and generally the blood amylase test value is greater than 3 times the upper limit of normal value with diagnostic significance. Pancreatic cysts, acute attack of chronic pancreatitis, obstruction of pancreatic ducts will also increase amylase; pancreatic cancer due to the large amount of pancreatic tissue destruction in a short period of time will also lead to increased amylase. 2. Non-pancreatic diseases: mumps, perforated peptic ulcer, mechanical intestinal obstruction, bile duct obstruction, acute cholecystitis, upper abdominal surgery, ethanol intoxication, renal failure and so on. When the amylase increase should be timely to go to the doctor, can not simply amylase as the diagnostic criteria need to be combined with the patient’s symptoms and related clinical examination in order to clarify the cause of the disease, under the guidance of professional doctors targeted treatment.