Rifampicin causes urinary protein is usually recovered after stopping the drug. Occasionally, kidney injury occurs with rifampicin, which is unlikely to cause adverse reactions such as elevated uric acid, urinary protein, hematuria, interstitial nephritis, and renal insufficiency. If it causes mild urinary protein, it is usually able to recover completely after stopping the drug. If rifampicin causes severe nephropathy, causing severe urinary protein, it may not be easy to return to normal after stopping the drug without taking treatment. Rifampicin adverse reactions include anorexia, nausea, vomiting, epigastric discomfort, diarrhea, elevated serum aminotransferase, hepatomegaly and jaundice, etc.; prohibited for those who are allergic to rifamycin-type antimicrobials, those with severe hepatic insufficiency, biliary tract obstruction, and pregnant women less than 3 months; used with caution in pregnant women more than 3 months of age and breastfeeding women. Rifampicin needs to be taken under the guidance of a physician, and regular rechecks of liver and kidney function, blood routine.