Hepatomegaly can be caused by many diseases and is an important clinical sign. The upper border of the liver is often consistent with the diaphragmatic fornix, starting from the 7th rib in the right mid-axillary line, to the 5th rib flat in the right mid-clavicular line, then to the left to the junction of the sternal body and the saber process after crossing the anterior midline, to the 5th rib gap flat slightly medial to the left mid-clavicular line, and the lower border of the liver is consistent with the anterior border of the liver, starting from the 11th rib in the right mid-axillary line, along the lower border of the right rib arch to the tip of the cartilage of the 9th rib, leaving the rib arch and reaching obliquely to the left and above below the saber process, and in the anterior midline about 3 cm beyond the saber process. The position of the liver is related to gender, age, and body type, and may change to some extent with breathing, visceral activity, and body position. What are the causes of non-infectious hepatomegaly? 1.Toxicity: can be caused by carbon tetrachloride, chloroform, ethanol, phenol, naphthalene, benzene, acetaminophen, sodium valproate, heavy metals, phosphorus, arsenic, isothiocyanic compounds, trinitrotoluene, monoamine oxidase inhibitors, p-aminosalicylate, pyrazinamide, ethylthioisonicotinamide, azathioprine, methotrexate, bicyclohexaethylene quinidine, amiodarone, aminophenolquinoline, thorium oxide, polyvinyl chloride, aflatoxin, muscarinic Isoniazid, cinchofen, pautazone, rifampin, tetracycline, diphenhydramine tincture, chlorpromazine, methyltestosterone, oral contraceptives, ketoconazole, methyldopa, phenytoin sodium, phenobarbital, furazolidine, sulfonamides, thioureas, phenobarbital, etc. 2, bruising: congestive heart failure, tricuspid stenosis or incomplete closure, myocarditis or cardiomyopathy, congenital heart disease, constrictive pericarditis, pericardial tamponade, hepatic vein obstruction, etc. 3.Cholestasis: intrahepatic cholestasis, extrahepatic cholestasis, common bile duct stones, bile duct cancer, pancreatic head cancer, pot belly cancer, etc. 4, metabolic disorders: fatty liver, Relye syndrome, acute fatty liver during pregnancy, hepatic amyloidosis, hepatomegaly, hemochromatosis, porphyria, hepatic glycogen excess, lipoid histiocytosis, familial splenic anemia, cholesterol ester storage disease, gangliosidosis, mucopolysaccharide deposition, galactosemia, hereditary fructose intolerance, cystic fibrosis, alpha 1 antitrypsin deficiency The following are some of the most common disorders of liver cirrhosis 5, cirrhosis: portal, schistosomal, post-necrotic, primary biliary, secondary biliary, cardiogenic cirrhosis, etc. 6.Tumors and cysts: primary hepatocellular carcinoma, secondary hepatocellular carcinoma, hepatoblastoma, carcinoid tumor, hepatic mixed tumor, hepatic adenoma, cystadenoma, hepatic hemangiosarcoma, hepatic hemangioendothelioma, hepatic cavernous hemangioma, adult hepatic polycystic disease, non-parasitic hepatic cysts, etc. 7.Other: such as sarcoidosis, nodular disease, autoimmune hepatitis, hepatic hematoma, various hematological diseases, multiple myeloma, myelofibrosis, AIDS, etc.