Azithromycin belongs to the antibacterial drugs, for pediatric viral infections caused by high fever is ineffective, should use antipyretic drugs, active supportive treatment, if necessary, under the guidance of the doctor to use the appropriate antiviral drugs. Azithromycin is mainly used for sinusitis, otitis media, pharyngitis, bronchitis, pneumonia, urethritis, etc. caused by sensitive bacteria, and is ineffective for viral infections. Its side effects include diarrhea, abdominal pain, vomiting, nausea, etc. It is prohibited for those who are allergic to macrolide antibiotics. For pediatric fever due to viral infection, antipyretics should be taken as prescribed by the doctor, commonly used antipyretics include ibuprofen and acetaminophen. In addition, active supportive treatment, such as drinking plenty of fluids, taking rest, and eating a balanced diet, is also needed. If the high fever is caused by influenza A or B virus or other viral infections, and the supportive treatment cannot meet the needs of disease recovery, appropriate antiviral drugs, such as oseltamivir, can be used as prescribed by the doctor. Children with high fever symptoms, it is recommended to take the child to the hospital for examination first, under the guidance of the physician to use the appropriate medication, should not be blindly used at home, in order to avoid delays in the condition. All of the above medications should be used under a doctor’s supervision.