HPV 53 and 33 positivity is not serious if there is no cervical lesion, but is more serious if combined with cervical cancer, etc.
Human papillomavirus (HPV) is categorized into low-risk and high-risk viruses, and HPV53 and HPV33 are high-risk viruses. HPV infection without cervical lesions is not serious. The most common types of viruses that cause cervical lesions are HPV16 and HPV18.
Cervical cancer screening currently requires a double screen, which is an HPV test and a cervical TCT. If you are infected with HPV53 and HPV33 but have no abnormalities on the cervical TCT, you will need to be retested in one year. If there is HPV infection and also abnormal cervical TCT, further colposcopy is recommended.
The vast majority of HPV infections can be cleared by autoimmunity, and only a very small number of persistent infections with high-risk viruses can cause cervical lesions. Once cervical precancerous lesions are detected, they need to be treated in a timely manner in order to avoid progression of the lesions.