Closed mouth acne can be treated with medications such as retinoic acid cream and adapalene gel. 1. Vitamin A acid cream: it can play a role in dissolving keratin and is used as an adjunctive treatment for conditions such as acne vulgaris. Common adverse reactions are localized skin irritation such as burning, erythema, and flaking. Contraindications include pregnancy and breastfeeding, hypersensitivity to the drug, and ocular contraindications. 2. Adapalene Gel: clinically, it is mainly used for the local treatment of acne vulgaris, which is mainly manifested by pimples, papules and pustules. The drug may cause localized skin dryness, burning sensation, as well as itching, flaking and so on. Contraindications mainly include: contraindication to hypersensitivity to the drug, avoidance of use during pregnancy. Closed mouth acne should first go to the hospital for examination, the drug needs to be used under the guidance of a professional doctor, not to abuse the drug themselves.