Generally speaking, the use of medicated mole spotting will not lead to contagious diseases if the operation is standardized. Drug mole spotting is to use trichloroacetic acid or chemical solution to apply on the surface of the mole to erode the local skin in order to remove the mole, which will not lead to infectious diseases under standardized aseptic operation. However, it is not easy to control the scope and depth of treatment in this way, which may lead to incomplete mole spotting, local infection, scar formation and other adverse reactions, and is not recommended to use. At present, smaller moles can be removed by laser treatment, but it is not suitable for treating larger moles or moles protruding from the skin because of its recurrence rate and the higher risk of scarring; surgical excision treatment is a relatively thorough way of removing moles, and histopathological examination can be carried out after the operation in order to clarify the nature of the mole. It is suggested that patients who need to remove moles should go to regular hospitals and choose the best treatment plan under the guidance of doctors, and avoid believing in biased prescriptions or private medication, which may lead to adverse consequences.