Testicular pain is mainly caused by epididymitis, and may also be caused by urethritis, prostatitis and so on. It can usually be treated with cephalosporins such as doxycycline or quinolones such as levofloxacin. 1. The most important cause of epididymitis is infection caused by Escherichia coli, which can be treated with quinolones such as levofloxacin and moxifloxacin. Contraindications include severe hepatic and renal insufficiency, pediatrics, elderly patients, patients suffering from central nervous system disorders such as epilepsy, and patients with severe underlying diseases cannot use such drugs. 2. Cephalosporin can treat urethritis caused by gonococcus. Drugs such as ceftriaxone can be used. Contraindications include hypersensitivity to this class of drugs. 3. Prostatitis can generally be treated with quinolones such as ciprofloxacin, ofloxacin, etc. If the prostatitis is infected by chlamydia, erythromycin, azithromycin and other treatments can be used. If the gonococcal infection can be treated with drugs such as ceftriaxone. Specific medication also need to consult the doctor, in the formal guidance to take.