Cold and fire with a sore throat with yellow sputum and blood is mostly caused by pathogens, you can relieve the symptoms through general treatment, medication and so on. 1. General treatment: During the period of illness, pay attention to a light diet, drink more water, avoid eating spicy stimulating food. Regular work and rest, avoid staying up late, and ensure sufficient sleep. 2. Drug treatment: antibiotics such as levofloxacin, amoxicillin and other drugs can be taken for anti-infection treatment. For sore throat, you can take Pientzehuang tablets to relieve the symptoms. For yellow sputum, expectorant drugs such as acetylcysteine and aminobromine can be taken for symptomatic treatment. Yellow sputum with blood may be caused by the damage of some small capillaries when coughing, and the symptom will change as the yellow sputum decreases. 3. Treatment for the cause: If it is common cold, generally no antiviral treatment is needed, and the above targeted medication can be used; if it is influenza virus caused by influenza, then the use of oseltamivir antiviral treatment is needed; the combination of other diseases, such as lung cancer, tuberculosis, bronchiectasis and so on, can also cause yellow sputum, blood in the sputum, and so on, and need to treat the cause of the radiation, chemotherapy and anti-tuberculosis treatment. Patients should go to the hospital as soon as possible, complete the relevant examinations, such as sputum smear, blood routine, lung CT, etc., to assess the condition, clarify the cause of the disease and follow the doctor’s instructions for reasonable and standardized treatment. The above mentioned drugs should be taken under the guidance of a professional doctor.