If pulmonary artery pressure has returned to normal after atrial defect repair, pulmonary hypertension-lowering medications can usually be discontinued. If pulmonary hypertension persists, the medication should be continued. Specific medications should be prescribed by the doctor. Atrial septal defect is a congenital heart disease that usually requires atrial septal defect repair or intervention to eliminate the condition. Atrial septal defects are prone to pulmonary hypertension and therefore require anticoagulants, diuretics, and calcium antagonists to relieve the condition. After surgery, the decrease in pulmonary hypertension is a gradual process, so pulmonary artery-lowering medications usually remain in use during convalescence. When the pulmonary artery pressure returns to normal, the medication can be discontinued under the guidance of a healthcare professional. It should be noted that after the operation, good nursing care should be taken, and active anti-infection treatment should be carried out. After atrial defect repair, people who still have pulmonary hypertension should go to the hospital for regular checkups and be treated according to the doctor’s instructions, and should not stop taking the medication at will.