Xinkang that isosorbide mononitrate extended-release tablets, Nicorandil and isosorbide mononitrate extended-release tablets do not exist which one is more effective, need to choose the appropriate drug for treatment according to the disease. Nicorandil’s effect is to dilate coronary arteries, the microvascular effect of the treatment of coronary arteries is better, can be applied to the treatment of coronary heart disease, angina pectoris. Nicorandil is mainly aimed at the treatment of coronary heart disease, can be taken for a long time, but taking Nicorandil some patients will have gastrointestinal discomfort, dizziness, panic, mouth ulcers or skin rashes and other symptoms. It is contraindicated for people with glaucoma, severe liver and kidney disease, and allergy. Isosorbide Mononitrate Extended-Release Tablets work to relax smooth muscle, dilate blood vessels, relieve angina, and are used in the long-term treatment of coronary heart disease, prevention of angina pectoris, and treatment of persistent angina after myocardial infarction. Its side effects include dizziness, nausea and vomiting, postural hypotension, bradycardia or shock, etc. It is contraindicated in patients who are allergic to nitrate drugs, acute myocardial infarction, severe hypotension, cardiomyopathy and intracranial hypertension. Nicorandil and isosorbide mononitrate extended-release tablets do not exist which effect is better, the use of drugs need to follow the doctor’s advice, the doctor will recommend suitable drugs for treatment according to the specific disease.