The possibility of closed-cell pimples is most likely to be considered, which belongs to the early manifestation of acne, and its treatment includes medication, physical therapy, and other treatments. 1. Medication: Clinically, retinoic acid is commonly used to improve the keratinization of the follicular ducts, but it is easy to irritate the skin, and should be avoided when using light, and can be used in combination with anti-inflammatory drugs, such as benzoyl peroxide and other drugs. Patients with the need for rapid treatment can also take oral retinoic acid drugs, such as isotretinoin capsules, under the guidance of a doctor. 2. Physical therapy: laser therapy, photodynamic therapy, red and blue light irradiation can be applied to control facial sebum secretion and reduce local inflammation. 3. Other treatments: under doctor’s guidance, after fully sterilized, use the acne remover to remove acne; or follow the doctor’s instructions to remove acne with topical chemical exfoliation methods such as fruit acid or salicylic acid. In addition, patients need to repair the skin barrier. Closed-cell acne is related to skin barrier dysfunction. Avoid excessive cleansing, and improve the skin’s water-oil imbalance by applying reasonable hydrating and moisturizing skin care products. It is recommended that patients with closed mouth pimples go to a regular hospital in time, and use reasonable and standardized medication under the guidance of the doctor to achieve better results.