Tetanus, also known as tonicity and commonly known as lockjaw, is an acute, toxic infectious disease caused by Clostridium tetani infection via wounds. Patients first have prodromal symptoms such as malaise, dizziness, headache, masticatory muscle spasms, irritability, and yawning. These prodromal symptoms usually last 12 to 24 hours, followed by the typical strong contractions of the muscles, initially the bite muscles, followed by the facial muscles, cervical and collar muscles, dorsal and abdominal muscles, limb muscles, diaphragm and intercostal muscles. The patient begins to feel difficulty in chewing and opening the mouth, followed by a tight closure of the teeth and a paroxysmal spasm of the facial expression muscles, giving the patient a unique “bitter smile” expression. Tetanus can be prevented, its prevention methods are mainly: 1, the most reliable prevention method is the injection of tetanus toxoid. Through the injection of toxoid, the human body produced antibodies, and in a longer period of time to maintain a certain concentration, can neutralize the tetanus toxin into the body, not to develop. Strengthening labor protection in industrial and agricultural production, avoiding trauma, popularizing the new method of delivery, and treating wounds correctly and timely are also important preventive measures. It is also necessary to inject only 0.5ml of toxoid; if the wound is seriously contaminated, then after 3-4 hours of injecting 0.5ml of toxoid, then inject 250-500U of human tetanus immunoglobulin intramuscularly in other parts to make the antitoxin neutralize the toxin first. The active immunity provoked by the toxoid can then play its preventive role before and after the antitoxin effect disappears. 2, correct treatment of wounds, timely and thorough debridement of all wounds should be debridement. For seriously contaminated wounds, especially war wounds, to remove all necrotic and inactive tissue, remove foreign bodies, cut open the dead cavity, open the wound, fully drainage, without sutures. If the delivery is found to be poorly disinfected, the umbilicus must be washed with 3% hydrogen peroxide solution and then disinfected with tincture of iodine. 3. Passive immunization. It is generally applied to those who have not injected toxoid before and have one of the following conditions: ① obvious contaminated wounds; ② fine and deep stab wounds; ③ serious open injuries, such as open cranio-cerebral injury, open fracture, burns; ④ wounds that cannot be cleared in time or treated improperly; ⑤ before performing surgery (such as foreign body removal) due to some old wounds. The passive immunization method now in use is the injection of tetanus antitoxin (TAT) refined from animal (bovine or equine) serum. It is a heterogeneous protein that is antigenic, causes allergic reactions, and does not remain in the body for long, starting to be removed by the body after 6 days. Therefore, this tetanus antitoxin is not yet ideal. The ideal product is human tetanus immunoglobulin, which has no allergic reaction and can stay in the body for 4-5 weeks after 1 injection, and the immune suburban energy is 10 times more than that of tetanus toxin. Its prophylactic dose is 250-500U, injected intramuscularly. Human tetanus immune protein sources are less, the preparation is complex, in the current situation can not be universally applied, the injection of tetanus antitoxin is still not lost as a major passive immunization method. Intramuscular injection of tetanus antibiotic 1500 IU (1 ml) as early as possible after the injury. The dose may be doubled in cases of severe wound contamination or if the injury has been present for more than 12 hours. The dose for adults is the same as for children. If necessary, another injection can be given 2 to 3 days later. Before each injection of antitoxin, ask if there is a history of allergy and make an intradermal allergy test: use 0.1 ml of antitoxin, add isotonic saline to dilute into 1 ml. inject 0.1 ml of the diluted solution intradermally in the flexor surface of the forearm; on the other hand, in the same part of the opposite forearm, with equal flushing and slightly raised hard mass, it is positive and should be injected by desensitization method. However, this method does not completely avoid the occurrence of allergic reactions, so it is best not to use this antitoxin for injection. The desensitization method of injection is to dilute 1ml of antitoxin 10 times with isotonic salt, divide it into 1, 2, 3 and 4ml, and inject it subcutaneously once every half hour in sequence. After each injection, observe any reaction. If the patient has pale face, weakness, urticaria or painful itchy skin, sneezing, coughing, joint pain or even shock, ephedrine 50mg or epinephrine 1mg (adult dose) should be injected subcutaneously immediately.