When endocrine disorders lead to long spots on the face, chloasma and other diseases are mostly considered, and it is necessary to improve the endocrine system by treating the cause of the disease, and the treatments include general treatment, medication and physical therapy. 1. General treatment: patients with melasma need to strictly protect themselves from sunlight and avoid exposing the lesions to ultraviolet rays. Wear umbrellas, sun hats and other items when traveling. Keep a good mindset, regular rest and relaxation, and avoid anxiety. 2. medication: patients can follow the doctor’s instructions for external use of hydroquinone, arbutin, arbutin and other deoxy arbutin creams, to facilitate the inhibition of tyrosinase activity, reduce the production of pigment. You can also use topical retinoic acid cream to inhibit melanin metabolism, but the drug has the risk of teratogenicity. 3. Physical therapy: patients can follow the doctor’s instructions to use laser therapy, which can improve chloasma through the principle of selective photothermal effect to make the pigment particles burst. If chloasma is caused by endocrine imbalance, patients need to have a regular daily routine, avoid direct sunlight on the affected area and keep a good mood. It is recommended that patients go to regular medical institutions for consultation and standardized treatment after clarifying the cause of the disease.