The main drug treatments for irregular menstruation caused by uterine fibroids are gonadotropin-releasing hormone analogs and mifepristone. 1. Gonadotropin-releasing hormone analogues: the medication can be used to control the symptoms of irregular menstruation, correct anemia, inhibit the growth of leiomyomas to make them shrink, etc. However, long-term use may have side effects such as osteoporosis. However, long-term use may have side effects such as osteoporosis. Commonly used drugs include leuprolide acetate. 2. Mifepristone: It is mainly used as a preoperative drug or for early menopause. Long-term use may increase the risk of endometriosis. It should be noted that the drug treatment of uterine fibroids is mainly used for the treatment of patients with mild symptoms, near menopause and poor systemic conditions that are not suitable for surgery. If the patient’s symptoms are severe, etc., surgical treatment should be considered. It is recommended that patients seek timely medical treatment for standardized diagnosis and treatment. The use of specific drugs should be under the guidance of the doctor.