Anti-allergy drugs generally do not cause a decline in immunity. The most basic immunity of the human body is formed innately, which is an immune system formed under the control of multiple organs and tissues throughout the body as well as the central nervous system, and can be strengthened by exercise later in life, or it may be declined due to some underlying diseases. The body’s immunity and allergies are closely linked, and allergic reactions may occur when immunity is reduced or when immunity is too strong. The more common anti-allergy drugs are loratadine, cetirizine, etc. These drugs selectively antagonize peripheral H1 receptors, which can provide allergy relief, and generally do not affect the body’s immune system. Although the anti-allergy drugs will not cause immunity decline, but some adverse reactions may occur, and there are some contraindications, the wrong use of drugs will not only harm the body, but also delay the condition, and even life-threatening. In addition to the need to use anti-allergy drugs to treat allergies, it is also recommended to go to the hospital for examination, clear allergens, away from allergens. It is recommended to have a balanced diet and do more outdoor exercise to improve the body’s immune system.