Centralized squamous lung cancer stage 3 is serious compared with early squamous lung cancer. Lung cancer staging is four stages in total, and squamous lung cancer stage 3 belongs to locally advanced stage, which can be developed into advanced stage without timely treatment. Centralized squamous lung cancer stage 3 has regional lymph node metastasis, and the lung lesions cause related symptoms, such as coughing and sputum, chest tightness and shortness of breath, and emaciation. Stage 3 centralized squamous lung cancer has developed regional lymph node metastasis or invaded surrounding vital organs, most of stage 3 lung cancers cannot be completely resected by surgery, and often need comprehensive treatment plans such as preoperative neoadjuvant radiotherapy or radical synchronous radiotherapy as well as combination of immune and targeted therapies to prolong the survival period. For centralized squamous lung cancer stage 3, it is recommended to visit hospitals in time for clear diagnosis and treatment so as not to delay the condition.