High creatinine and uric acid may be induced by diseases such as glomerulonephritis, acute and chronic renal failure as well as high-protein and high-purine diets, which can be lowered by lifestyle modification, medication, hemodialysis and so on. 1. Glomerulonephritis: If patients are caused by glomerulonephritis, they can be treated with glucocorticosteroids, such as prednisone acetate tablets and other drugs, or immunosuppressants, such as cyclosporine soft capsules and other drugs. 2. Acute and chronic renal failure: due to the damage of renal function, the metabolism of uric acid and creatinine is abnormal, resulting in the elevation of creatinine and uric acid, can be treated with drugs such as urotoxin, febuxostat and so on, and can be treated with hemodialysis if necessary. 3. Patients with high creatinine and uric acid need to make dietary adjustments, reduce the intake of high-salt, high-purine and high-protein foods, such as spinach, seafood, salted vegetables and other foods, and reduce the consumption of fruits with high sugar content. Found that creatinine and uric acid high need to go to the hospital in time to identify the cause, under the guidance of the doctor standardized treatment.