Most 3mm gallstones are asymptomatic and generally do not require treatment. For patients with symptomatic gallstones, cholecystectomy is the preferred treatment. For asymptomatic patients with gallstones, medication can be chosen. 1. Cholecystectomy: When patients with 3mm gallstones meet the indications for cholecystectomy (e.g. gallbladder atrophy, porcelain gallbladder, obvious thickening of the gallbladder wall, gallbladder stones combined with gallbladder polyps, etc.), cholecystectomy can be chosen, and clinically, there are mainly open surgery and laparoscopic cholecystectomy. 2. Drug treatment: patients can choose drugs with pain relieving effect to relieve biliary colic under doctor’s guidance, including diclofenac and ketoprofen. Drugs with choleretic effect can be chosen to promote bile discharge and control inflammation, such as ursodeoxycholic acid tablets and deoxycholic acid tablets. Symptomatic gallstones are recommended to be treated promptly, and should not be self-medicated.