Scattered microscopic nodules in both lungs and subpleura need to be treated depending on the cause. Common causes include tuberculosis, pneumoconiosis, lung metastases, pneumonia and so on. 1. Tuberculosis: Scattered microscopic nodules in both lungs and subpleura may be acute cornual tuberculosis, which belongs to a kind of tuberculosis, with more acute onset and more serious symptoms, and need to strictly comply with the doctor’s instructions and timely anti-tuberculosis treatment, such as oral isoniazid, rifampicin, pyrazinamide, streptomycin and other anti-tuberculosis drugs. 2. Pneumoconiosis: Pneumoconiosis should be considered when there are multiple unevenly distributed, high density nodules in both lungs, combined with calcified foci, and when working in an environment with mineral dust. After diagnosis of pneumoconiosis, one should stay away from dusty working environment, take active oxygen therapy, and use drugs such as terbutaline, aminophylline, bromohexine to relieve cough, expectorant and asthma according to doctor’s prescription. Alveolar lavage can also be considered, and lung transplantation can be considered in serious condition. 3. Lung metastases: multiple nodules in the lungs should be combined with the patient’s medical history to consider the possibility of lung metastases, due to the multiple nodules, generally not suitable for surgical treatment, chemotherapy, radiotherapy can be used. 4. Pneumonia: Multiple tiny nodules in both lungs, or it may only be simple inflammatory nodules. If the patient has no clinical symptoms, there is no need to carry out special treatment, and regular review to observe the changes in the nodules can be. If there are fever, cough and sputum, the patient should follow the doctor’s instructions to actively fight infection, such as oral cefuroxime and other antibiotics, and oral aminoglutethimide, ibuprofen and other symptomatic treatment. The presence of scattered small nodules in both lungs and under the pleura, need to actively consult the doctor, to clarify the cause of the disease for targeted treatment. Drugs should be used under the guidance of a doctor, avoid self-medication.