What is Parkinson’s disease?

  Parkinson’s disease (PD) is a common degenerative disease of the nervous system, more common in the elderly, with an average age of onset of about 60 years, and less common in young people with PD starting under the age of 40.  The prevalence of PD in people over 65 years of age in China is about 1.7%. Most patients with Parkinson’s disease are epidemic cases, and less than 10% have a family history of the disease.  The main pathological change in Parkinson’s disease is the degenerative death of dopamine (DA)-ergic neurons in the midbrain substantia nigra, which leads to a significant decrease in striatal DA content and causes the disease.  The exact etiology of this pathology may be genetic, environmental, ageing, and oxidative stress.  The onset of the disease is insidious and the progression is slow. The first symptom is usually tremor or clumsiness of movement in one limb, which then spreads to the opposite limb. The main clinical manifestations are resting tremor, bradykinesia, myotonia and postural gait disorders.