For neuropathic pain, the traditional thinking is to directly block, disrupt, or inhibit pain receptors or pain pathways. Although the mechanisms by which pain occurs are complex, pain is undoubtedly always the result of nerve damage or provocation following neuropathy. Is it possible to adopt a non-blocking pathway and strategy to treat pain? Thus the idea of restorative pain therapy has been thought of. Pain nerve repair treatment and pain etiology treatment are not exactly the same. The former is more aggressive in its therapeutic thinking, emphasizing painless nerve remodeling and benign nerve shaping, which are not equivalent to mere anatomical structural repair. In 1994, the International Association for the Study of Pain defined neuropathic pain (neuralgia) as “pain due to a primary lesion or dysfunction of the nervous system”. About 1/3 of patients presenting with a pain complaint are in acute pain and 2/3 are in chronic pain. And 1/3 of the patients with chronic pain are neuropathic pain. Neuropathic pain is mainly manifested as spontaneous persistent or explosive pain, and pain of amplified degree induced by injurious or non-injurious stimuli. Current basic and clinical research confirms that pain restoration based on cellular therapy has a significant ameliorative effect on neuropathic pain and can even be cured. The main means of pain repair treatment are: 1, repair factor drug brachytherapy injection: intrathecal injection of nerve growth factor can reduce reactive glial cell proliferation, correct the abnormal expression of neurotrophic factor receptors in the rat model of neuropathic pain, maintain the stability of the spinal cord internal environment, and effectively relieve pain. 2.Ozone: It is effective in reducing tissue congestion, promoting edema dissipation, lowering local temperature and increasing joint movement. The strong oxidizing effect of ozone can rapidly deactivate inflammatory chemicals. 3.Local deep muscle heat therapy and soft tissue endothermic therapy: improve local tissue blood circulation, reduce the release of inflammatory mediators, and reduce spontaneous electrical activity of muscles.