Hormonal drugs can cause an increase in blood pressure. One of the side effects of hormonal drugs is that they can cause an increase in blood pressure. Elevated blood pressure caused by hormonal drugs is one of the causes of secondary hypertension. The hormones that clinically cause elevated blood pressure include estrogen, progesterone, androgens, oxytocin, posterior pituitary hormone, glucocorticoids, salt corticosteroids, and levothyroxine sodium tablets. Since the application of these hormones can cause water and sodium retention, activation of the renin-angiotensin-aldosterone system, as well as insulin resistance, adrenocorticotropic hormone response, and increased sympathetic excitability, respectively, all of which can increase blood pressure, attention should be paid to adverse effects such as increased blood pressure when applying hormones to treat the disease.