Cancer pain, or advanced cancer pain, is one of the main causes of suffering for patients with advanced cancer. At this stage, patients are in considerable physical and mental pain, and a significant number of patients die not directly from cancer, but from severe pain. About 80% of advanced cancer patients have severe pain, and it is estimated that at least 15 million people in the world experience pain every day. Cancer pain has been recognized as a painful disease. Nerve destructive blocks offer an excellent route to control chronic cancer pain. The success of these nerve blocks depends on the understanding and cooperation of the patient, the acceptance of other departments (oncology, etc.), and the experienced skill of the pain physician. With proper training and manipulation, treatment under the precise guidance of imaging equipment (CT, C-arm) significantly improves safety. Commonly used methods are as follows: 1. Ethanol block of the abdominal plexus Ethanol block of the abdominal plexus is used to treat pain caused by abdominal tumors, especially pancreatic cancer pain, and about 60-85% of patients can obtain no pain. It needs to be performed under X-ray fluoroscopy. Abdominal plexus block provides excellent relief of epigastric pain and back involvement pain caused by malignant tumors of anterior intestinal origin. It is most commonly used in pancreatic cancer, where, contrary to conventional wisdom, the most common symptom is pain rather than painless jaundice. nCPB is also effective for tumor-based pain in the distal esophagus, stomach, liver, bile duct, small intestine, proximal colon, adrenal glands, and kidney. Pain due to intra-abdominal malignancy that is not well treated with other methods should be considered for abdominal plexus block. It has been reported that abdominal plexus block is also effective for pain of colon and rectal cancer. 2.Destructive peripheral nerve block When cancer pain is more limited and the effect of drug treatment is not effective, using different concentrations of phenol, ethanol, adriamycin and mitomycin solution to block peripheral nerves or using radiofrequency to destroy nerves can often achieve satisfactory results. Although peripheral nerve release is limited in the treatment of pain due to malignant causes, its role is clear and certain. To ensure effective analgesia, the nerve block must be located proximal to the original stimulus. It can be performed on an outpatient basis or in the patient’s home. It is mainly used in patients with limited pain or residual localized pain after blocking with other methods. Commonly used nerve blocks include maxillary nerve, mandibular nerve, auriculotemporal nerve, greater occipital nerve, suprascapular nerve, thoracic nerve, intercostal nerve, femoral nerve, obturator nerve, sciatic nerve, and peroneal nerve. 3.Subarachnoid nerve destructive block The analgesic effect and duration of subarachnoid phenol or ethanol block are better than local nerve block and nerve root block. This method is effective in controlling cancer pain, but requires an experienced anesthesiologist to perform. Phenol-glycerol block is more commonly used nowadays. The analgesic effect accounts for 50%-60%, good for 21%-30% and poor for 18%-20%. The effectiveness is closely related to the location of the tumor, the puncture gap, the dose of drug injection and the method of pain evaluation. Most of the reported pain relief time is from 2 weeks to 3 months, and a few patients can last from 4 to 12 months. Complications after blockade are mainly caused by damage to non-nociceptive nerves. All treatments should be performed in the operating room. Complications of bilateral block include urinary retention, rectal dysfunction and muscle paralysis, which mostly reduce or disappear within a week. 4.Epidural nerve destructive block Epidural block is a method of injecting nerve destructive drugs into the epidural cavity to block spinal nerve conduction and produce segmental analgesia. Compared with peripheral nerve block, epidural block can block both somatic and autonomic nerves, and the block is more extensive and effective. Compared with subarachnoid block, meningeal stimulation and spinal cord or spinal nerve injury can be avoided, and because the nerve-destroying drugs do not directly contact the nerve roots and act outside the dura, the possibility of bladder and rectal sphincter involvement is less than that of subarachnoid block, but its effect is also inferior to that of subarachnoid block. In addition, nerve-destroying drugs can also be injected via the epidural catheter in divided doses. In conclusion, some patients with cancer pain face tens or hundreds of analgesics daily, but still cannot effectively relieve the pain or tolerate the side effects, enduring both physical and mental pain, and they are often troubled by the inappropriateness of the treatment method, hoping for a miracle,. Nerve destructive block provides an excellent way to control chronic cancer pain.