The pancreas is an organ of the body, and the islets are the endocrine part of the body, consisting of many cell clusters of varying size and shape. The pancreas and the islets are both related and different. 1. The connection between the two: The islets are a cell mass that exists in the human pancreas and can secrete insulin, and there are about 1-2 million of them in the human body. Difference: There is a conceptual difference between the islets and the pancreas, the islets belong to the tissue and the pancreas belongs to the organ. The pancreas is a gland with endocrine function and its pathological as well as physiological role is related to human life, while the islets control carbohydrate synthesis in human body by producing hormones to synthesize insulin.