Chronic uremia is caused by more causes, more common are primary kidney diseases, such as glomerulonephritis; and secondary kidney diseases, such as diabetic nephropathy, hypertensive nephropathy; and obstructive nephropathy. These kidney diseases cause damage to the kidney unit, which can cause a situation of high perfusion, high pressure and high filtration of the glomerulus, causing glomerulosclerosis, causing interstitial fibrosis of the renal tubules and further deterioration of kidney function, eventually forming chronic uremic syndrome. Chronic uremia is the final destination of all chronic kidney diseases and the most serious stage of kidney disease. Uremia mostly causes different symptoms such as hypertension, heart failure, pulmonary edema, anemia, loss of appetite, bleeding, etc. Chronic uremia is irreversible and requires treatment such as hemodialysis treatment or peritoneal dialysis treatment, and kidney transplantation can be considered if economic conditions allow.