Cephalosporins such as cefotaxime, cefazodime, cefdinir, cefixime, and cefodizime do not cause disulfiram reactions. The disulfiram reaction, or disulfiram-like reaction, is due to the fact that some cephalosporins contain a methylthiotetrazole active group similar to the molecular structure of disulfiram, which is able to inhibit the activity of acetaldehyde dehydrogenase in alcohol, resulting in the metabolism of the enzyme being impeded, so that acetaldehyde can not be normally generated to metabolize acetic acid out of the body, and thus a large amount of accumulation in the body, which may lead to intoxication. Cephalosporins such as cefotaxime, cefazodime, cefdinir, cefixime, cefodizime, etc. do not show disulfiram reaction after drinking alcohol due to the absence of methanethiotetrazole group in their chemical structure. The use of cephalosporins must follow the doctor’s instructions to avoid improper use and harm to the body.