Physiological jaundice in healthy full-term newborns subsides within 2 weeks of age (14 days after birth), and newborns over 2 weeks of age who still have jaundice should be seen in a timely manner. However, parents often think that breast milk jaundice does not require special treatment, and often do not seek medical attention until 1 month after birth or even until 2 to 3 months after birth, resulting in the continuation of the disease into infancy and the development of sepsis or infantile hepatitis syndrome. Jaundice can be associated with infections, which may occur in utero, during labor and after birth. Infection-related neonatal jaundice can be caused by a variety of pathogens, including hepatophilic viruses, non-hepatophilic viruses, and other pathogenic infections. However, most of them are caused by viral infections, with hepatitis B virus and cytomegalovirus as the main pathogens in China. Hepatophilic virus Hepatitis B virus is the most common, followed by hepatitis C virus, both of which are often infected by vertical transmission from mother to child. Hepatitis A, D, E and G viruses can also cause infection in children. 2, non-hepatophilic viruses The most common is cytomegalovirus, followed by EBV, rubella virus, herpes simplex virus, enterovirus (enterovirus 71, coxsackievirus B5 and B6, echovirus, etc.), enteroadenovirus, human immunodeficiency virus (HIV), etc. Human cytomegalovirus is an important pathogen of non-hepatophilic virus. 3, other infectious factors Bacterial (such as staphylococcus, Escherichia coli, pneumococcus, S. typhi, Mycobacterium tuberculosis, Listeria monocytogenes, etc.) infections lead to excessive inflammatory response and cause severe sepsis, which can lead to multi-organ damage, among which liver damage is the most common. Although brain and eye damage are common in Toxoplasma infection, jaundice and hepatosplenomegaly and liver damage occur in 50%. Syphilis spirochete infection is mostly early congenital syphilis, and in addition to the most common skin and mucous membrane damage, there may be slow growth of body mass, low cry, hoarseness, often accompanied by hypothermia, anemia, large liver and spleen and lymph nodes, and liver function damage. Jaundice is only a clinical symptom, early and correct diagnosis of the cause of jaundice is important to guide the treatment of the disease and determine the prognosis. The American Academy of Pediatrics recommends that if a healthy full-term newborn has jaundice over 3 weeks of age or jaundice accompanied by white stools, he or she must go to the hospital for liver function and other related tests.