Stale acne marks on the face can be removed by general treatment, oral medication, topical medication and physical therapy. 1. General treatment: Healthy diet, eating more vegetables and fruits rich in vitamin C, and maintaining a regular routine can help reduce pigmentation. 2. Oral medication: Isotretinoin can inhibit sebum secretion of sebaceous glands and regulate the keratinization of sebaceous gland ducts in hair follicles, which can be used as an auxiliary treatment for removing acne marks. 3. Topical medication: Adapa Gel, Vitamin E cream, Vitamin A acid cream and other topical application can help to reduce hyperpigmentation, so as to achieve the effect of removing acne marks. 4. Physical therapy: strong pulse light, fractional laser, pulsed dye laser and other physical methods can directly destroy pigment particles, which can effectively make local acne marks fade. The face with old acne marks should go to the regular medical institutions in time, under the guidance of the doctor for regular treatment.