Helicobacter pylori is a Gram-negative, microaerobic bacterium that lives in various regions of the mouth, stomach and duodenum. Since the successful isolation of H. pylori from the gastric mucosa by Warren et al. in 1982, it has been confirmed that H. pylori is associated with a number of common diseases in children and adults: it can cause peptic ulcers, gastritis, and even gastric cancer in adults; it is also closely associated with recurrent mouth ulcers, periodontitis, iron deficiency anemia, idiopathic thrombocytopenic purpura, and growth retardation. The infection rate in the Chinese population is reported to be 40%-90%, with an average of 59%; while the current infection rate in Chinese children is 25%-50%, and increasing at an average rate of 0.5%-1% per year. The World Health Organization (WHO) has declared B. pylori as a microbial carcinogen and the first prokaryotic organism recognized to be carcinogenic to humans. As the entrance to the digestive tract, colonization of H. pylori in the oral cavity can affect the efficacy of H. pylori eradication therapy, especially in the long term. Since H. pylori in the oral cavity is found in dental plaque, oral mucosa, dental calculus, gingival pockets, saliva, and diseased dental pulp, especially dental plaque has a unique “biofilm” structure and the dental pulp is in a relatively closed cavity, H. pylori can escape the killing of antimicrobial agents, so systemic drugs have little effect on it. Over time, the resistance rate of H. pylori to commonly used antibiotics is increasing, and the eradication rate is decreasing. It is especially important to control oral-oral transmission and oral-gastric transmission. Paying attention to oral hygiene and preventing disease from entering the mouth are increasingly important measures to prevent H. pylori infection, gastric disease and gastric cancer. So how can we detect H. pylori infection in the oral cavity as early as possible and effectively remove H. pylori? There are the following measures: 1, pay attention to the screening of H. pylori infection, and timely control. 2, regularly do periodontal cleaning, remove plaque and tartar, eliminate periodontal pockets. 3, timely treatment of dental caries, dental pulp and periodontal disease, pay attention to denture cleaning and hygiene, remove H. pylori stash. 4.Separate meal system. 5.Avoid mouth-to-mouth feeding of infants. The high rate of H. pylori infection in African children is also due to the mother’s habit of chewing first before feeding.