Isthmic disintegration can be treated without surgery, this is more suitable for patients with mild symptoms, if the patient’s symptoms are more severe, surgical treatment is recommended at this time. The treatment of isthmus disintegration is generally based on the severity of clinical symptoms to take conservative treatment or surgical treatment. For patients with mild clinical symptoms of isthmus disintegration, they can be relieved by bed rest, wearing waist braces, exercise rehabilitation training, etc. Oral non-steroidal anti-inflammatory drugs, such as Fitalin tablets, Fenbid etc., can also be taken to obtain a better prognosis. When the symptoms of patients with isthmic disintegration are more serious, such as the lumbar pain is difficult to relieve, and the symptoms of nerve pain in the lower limbs appear, at this time, it is generally recommended to take the way of surgical treatment, such as simple implant fusion, screw direct fixation technology, interbody fusion, etc., and the therapeutic effect is also more satisfactory. Patients with isthmus avalanche should combine their own specific conditions and choose the suitable treatment under the guidance of doctors to avoid delaying their condition.