The current clinical use of sleeping drugs for the treatment of insomnia is divided into several categories, the first is barbiturates, the second is benzodiazepines, the third is a new type of non-benzodiazepine hypnotic drugs, in addition to anti-anxiety drugs, antidepressants, melatonin, Chinese medicinal preparations. The side effects of melatonin are relatively small among all the drugs, because it is a secretion of the human or mammalian pineal gland and has a significant effect on improving sleep. However, the use of large amounts or long-term application can lead to dependence, and there can be central nervous system or endocrine changes.