Physiologic and pathologic causes (e.g. cervical spondylosis, thoracic outlet syndrome, endocrine system diseases, renal diseases, heart diseases, etc.) are considered for soreness and swelling of both hands. 1. Physiological causes: If the upper limbs are prolonged standing for a long time, causing poor blood return, the hands will be sore and swollen, and the symptoms can be alleviated by elevating the upper limbs. 2. Cervical spondylosis: degeneration of cervical vertebrae or herniated nucleus pulposus compressing spinal nerves can cause soreness and swelling of both hands, and weakness of finger grip. 3. Thoracic outlet syndrome: the brachial plexus nerves and blood vessels between the clavicle and the first rib are compressed, which can cause soreness, weakness, numbness and pain in both hands. 4. Endocrine system diseases: For example, hypothyroidism can also cause soreness and swelling of the hands. 5. Kidney disease: nephritis, nephrotic syndrome causes edema and swelling of hands. 6. Heart disease: for example, cardiac failure causes generalized edema and swelling of the hands. It is better to go to the hospital to check the cause of the soreness of the hands, and then treat the cause of the disease.