Penicillin is the drug of choice for the treatment of syphilis, for mild allergy can be tried after desensitization and then penicillin treatment, for penicillin severe allergy patients commonly used ceftriaxone sodium alternative treatment. Ceftriaxone sodium is a highly effective anti-syphilis spirochete drug proven in recent years, and is the preferred alternative treatment for patients with penicillin-allergic syphilis. Tetracyclines and macrolides (such as doxycycline, tetracycline hydrochloride, erythromycin, azithromycin, etc.) can also be used as alternative therapeutic drugs, but the efficacy is often inferior to that of penicillin. It should be noted that liver and renal insufficiency is prohibited, and tetracycline is prohibited for pediatric patients younger than 8 years old and pregnant women. Syphilis should be treated as early as possible, in sufficient quantity and in a standardized manner, in order to avoid the occurrence of serious complications, and should not be delayed, so as not to cause adverse consequences.