Patient, female, 69 years old Complaint: dry mouth, tongue pain and oral mucosal pain for more than 8 years History: Oral mucosal discomfort appeared 8 years ago, self-taking anti-inflammatory drugs, but no significant improvement. Over the years, he has been taking anti-inflammatory drugs intermittently, etc. In recent years, his dry mouth and sore tongue have worsened, and he came to our hospital for consultation. Sun Weilian, Department of Oral Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine Examination: diffuse erythema of oral mucosa on the back of tongue, both cheeks, palate, etc., congestion, dry surface, no pseudomembrane; atrophy of filiform papillae on the back of tongue and tongue margin. Fungal smear: mycelium (+); Diagnosis: oral candidiasis Laboratory tests: serum ferritin 91.7 ng/mL, vitamin B12 168 pg/mL, white blood cell count 11.5X109/L, neutrophils 74.8%. Auxiliary T lymphocytes 25.4%. Treatment: oral mucosal disease precautions education; anti-mycotic treatment; vitamin supplementation; immunomodulatory treatment, etc. 2012.7.12 Initial diagnosis 2012.7.19 1 week later