Gastrointestinal cancer is most common in stomach, colorectal and esophageal cancers, and small intestine cancer is rare. At present, because of the poor promotion of the concept of early diagnosis and early treatment in China, most patients lose the opportunity of surgery after diagnosis, and those who receive surgery are also more in the middle stage, so post-operative recurrence is also common. Hundreds of people still have the concept and idea that only surgery is the treatment for GI tract and other solid tumors. It is undeniable that surgery is the only curative method, but if unfortunately, surgery is not possible or recurrence after surgery, which? Therefore, people should update the concept that radiotherapy can prolong the survival, improve the quality of life, and provide the possibility of radical surgery (preoperative conversion therapy). Blind surgery not only fails to cure, but also shortens survival time. Whether to operate for postoperative recurrence is a complex issue. Generally, the purpose of surgery is twofold: 1. to relieve life-threatening complications, such as hemorrhage, intestinal obstruction, etc.; 2. and the possibility of radical cure (R0 resection). The choice of reoperation after recurrence is carefully made, with multidisciplinary consultation and full consideration of the patient’s benefit. Whether to choose surgery differs from tumor to tumor consideration, for example, timely and accurate surgical intervention for colorectal cancer liver metastasis can prolong patient survival and improve 5-year survival by 50%, but there is almost no possibility of secondary surgery for esophageal cancer, and gastric cancer generally does not choose reoperation easily, the considerations are many and complex, not something that can be clearly stated here, and it is highly individualized. In conclusion, people need to update their concepts and doctors need to establish a multidisciplinary consultation system to standardize treatment.