Lung cancer genetic test does not necessarily have puncture, but can also be done through bronchoscopy or surgery to obtain specimens, and can also be done through blood or pleural fluid testing. Lung cancer genetic test is a kind of examination for sequencing the genes of cancer cells. Through genetic sequencing, it can clarify whether there is any genetic mutation in the mutation of cancer cells, and for patients with genetic mutation, they can be treated with targeted drugs, which can provide support for clinical treatment. Lung cancer genetic testing can be performed in various ways to obtain specimens, and puncture biopsy is a commonly used method. Puncture biopsy needs to be localized by chest CT, and the tissue at the lesion site is obtained under the guidance of CT. Genetic testing can also be performed by tracheoscopy or surgery to obtain tissue from the lesion. Some patients can also be genetically tested by cancer cells in the blood or pleural fluid, but the positive rate is low, for when the tissue specimen cannot be obtained by other methods, specimens of blood or pleural fluid can be tested. However, puncture is not the only method; specimens of diseased tissue can also be obtained through bronchoscopic guidance, but the disadvantage of both methods is that the amount of specimen may be insufficient, and some patients can obtain specimens through surgery.