If diabetic nephropathy belongs to the early stage, i.e., stage I~III, at this time, proteinuria is relatively small, and after drug control, it is possible to turn negative, but the specific time of turning negative is not certain; if diabetic nephropathy develops into a large amount of proteinuria, even if the active treatment of drug treatment, it is not possible to turn negative. Diabetic nephropathy early manifestation of intermittent proteinuria or persistent microalbuminuria, early use of renin-angiotensin-aldosterone receptor antagonist (Benadryl, valsartan) control of urinary protein; at the same time, control blood sugar, you can choose to Dagliflozin lowering of glucose at the same time has the effect of lowering protein, proteinuria may be negative, but the specific time of conversion is not certain, but if diabetic nephropathy without active treatment, after medication control, may be negative, but the specific time of conversion is not certain. However, if diabetic nephropathy is not actively treated, or found when the urine protein has been significantly elevated, manifested as a large amount of proteinuria, or even combined with renal insufficiency, etc., the proteinuria can not be converted to a negative level despite strict antihypertensive, glucose-lowering, and protein-lowering treatments. Patients with diabetic nephropathy are advised to consult regular hospitals and receive standardized treatment under the guidance of physicians to slow down the progression of the disease.