As the name implies, medication-refractory epilepsy refers to the group of patients with epilepsy who have a correct diagnosis without question, are on regular antiepileptic drugs (two or more) in adequate doses and for a full course of treatment, but still do not achieve a satisfactory outcome. The medical community recognizes that refractory epilepsy accounts for approximately 20-30% of patients with epilepsy. In clinical work, many patients with epilepsy tell their physicians, “I’ve taken all kinds of drugs, and none of them work,” such patients may not be refractory to epilepsy. Because many patients have incorrect diagnoses, have problems choosing medications, or even use informal medications or medications of dubious origin, they should not be easily labeled as having “refractory epilepsy. For these patients, a detailed epilepsy history should be established, and a proper diagnosis and appropriate medication regimen should be developed to achieve better control.