Poisoning manifestations of epiphyllum are mostly reflected in the excitation of the vagus nerve and the toxic effect on the heart. The toxicity of epiphyllum comes from aconitine, and the main clinical manifestations of poisoning are: numbness of lips, tongue and limbs, chest tightness, dyspnea, dizziness, panic, burning sensation in the throat, esophagus, stomach, nausea and vomiting, confusion, pupil dilatation, and in severe cases, shock, cardiac arrhythmia, coma, and ultimately death due to cardiac paralysis and respiratory failure. The causes of epiphyllum poisoning are excessive dosage, incorrect decoction method, inappropriate pairing, individual differences, etc. When taking the dosage needs to be controlled, lactating women, pregnant women, children are prohibited, epiphyllum is not suitable for use in conjunction with or pairing with Bei Mu, Gua Pou, Bai He, Semenxia, Ampelopsis, and in the decoction of tonic, epiphyllum must be fried for 40-60 minutes, and the mouth tastes like no numbness and spiciness is preferred. In case of epiphyllum poisoning, the nervous system and the heart are mostly injured. The prescription containing epiphyllum must be taken only after the Chinese medicine practitioner has made a diagnosis, and individuals should not take epiphyllum on their own in order to avoid adverse consequences.