Pain is the most common type of clinical condition, and in our orthopedic department, the most common, is pain due to cervical spine, lumbar spine or bone and joint disease. However, it is worth reminding that not all skeletal pain is as simple as joint disease. We once met such a patient. The person in question was very young and had been injured in the past while playing basketball, and then there was always joint pain in his legs. Until one day, he accidentally fell off his bicycle while cycling, and as a result, he actually induced a fracture. During a detailed examination at the hospital it was discovered that what he was actually suffering from was a giant cell tumor of the bone. In fact, there are many causes behind the skeletal causes of pain. The most common ones include the following: 1, common bone and joint, spinal lesions This is the most common cause of pain, such as knee pain caused by osteoarthritis, pain caused by cervical and lumbar spine lesions, are included in this category. 2.Bone pain caused by osteoporosis Osteoporosis can cause bone pain, including systemic and localized pain are present. This kind of pain patients, mainly for osteoporosis treatment, appropriate supplementation of calcium and vitamin D, the bone protection, but also can effectively relieve pain. 3.Bone tumor causing pain This kind of pain is most alarming, which also includes primary bone tumor and bone metastasis of other tumors. As there is no lack of malignant tumors among them. One characteristic of this kind of pain is that the pain will be significantly aggravated at night, and examination methods such as X-ray and PET CT can help to detect the tumor. It is important to note that it is now clinically found that many patients, especially middle-aged and elderly patients, may have several etiologies at the same time, when they are most likely to be misdiagnosed and treated simply as common arthritis, while concealing the real condition. Therefore, for these patients, if they have chronic, persistent skeletal pain, it is best to take a bone density and x-ray examination to avoid missing the diagnosis.