Trigeminal neuralgia is known as the “world’s greatest pain”, which has a great impact on the life of patients, so it is getting more and more attention. However, the symptoms of trigeminal neuralgia are very similar to those of toothache, so it is easy to misdiagnose if diagnosed in an informal hospital, so it is crucial for patients with facial pain to know how to distinguish between toothache and trigeminal neuralgia. The main points of differentiation between trigeminal neuralgia and toothache are introduced as follows: 1. The duration of trigeminal neuralgia attack is short, only a few seconds to 1~2 min each time, and the disappearance of pain is also very sudden, but it is mostly triggered by eating, speaking, brushing teeth and washing face. The intervals between attacks are completely normal. When the seizure is severe, the affected side is lacrimation, nasal mucosa congestion, runny nose, saliva distribution increases, if the disease is long and frequent seizures, there can be dystrophic changes, such as local skin roughness. 2.Finding the trigger point is also one of the methods to identify trigeminal neuralgia. Slight stimulation can cause the onset of pain, so what is the trigger point of trigeminal neuralgia? Slight stimulation of the face or a point on the lips, tongue, gums, or nose can cause an attack of pain, and this allergic point that causes severe pain is called the trigger point. The pain starts from the trigger point and radiates along the distribution area of a branch of the trigeminal nerve and does not exceed the midline. Patients often open their mouths, smack their tongues, cover the affected side of the face with their hands, have painful expressions, fidget, and sometimes wake up in pain during sleep. Patients are mostly afraid to wash their faces, brush their teeth, eat and even speak with high tension. 3. Typical clinical manifestations of toothache Toothache refers to the pain caused by dental diseases such as tooth decay, residual root and crown. Toothache is persistent pain, with obvious onset at night, aggravated by hot and cold stimulation, deep and non-dischargeable pain at the painful site, and dental diseases can be found through oral examination, such as dental caries, residual roots, and residual crowns. In many cases, the trigeminal nerve extends from the brain and divides into three branches. The first branch manages the sensation in the frontal and ocular regions on one side, while the second and third branches manage the sensation in the lower eyelid, paranasal, upper and lower lips, and the upper and lower rows of teeth, respectively. Therefore, patients often feel severe pain in one side of their teeth, which is often misdiagnosed as a toothache, and although the “diseased” tooth is removed, the nerve still exists, so the pain does not go away.