The sign of immune response is the beginning of abnormal liver function. After liver-protective and enzyme-lowering treatment, liver function still cannot return to normal, or it can return to normal but for a short period of time, and then the abnormality appears again. In clinical practice, as long as the surface antigen is below 3000 and there are no contraindications to cirrhosis or interferon, all can be treated with interferon to achieve a negative surface antigen. The use of interferon should be considered only when contraindications to interferon are excluded and there is no cirrhosis.