After having liver and gallbladder surgery to discover cholangiocarcinoma, it is necessary to complete the surgical treatment of the primary disease first, and thereafter choose the specific way of treating cholangiocarcinoma according to the patient’s condition. For cholangiocarcinoma patients who meet the indications of surgery, surgical resection is currently preferred, and if the patients can tolerate surgical treatment, they need to actively carry out relevant treatments under the guidance of doctors for radical resection. For patients with severe symptoms and extensive lymph node metastasis, the effect of surgical treatment is not obvious, and comprehensive treatment such as radiotherapy and immunotherapy can be carried out to improve the symptoms and prolong the survival period. At present, the malignant degree of cholangiocarcinoma is high, and the overall prognosis of patients is poor, so patients need to actively cooperate with doctors for treatment, keep a calm mind and cultivate good living habits.