For advanced stage of mixed lung cancer, chemotherapy, targeted drug therapy and radiotherapy can be considered. 1. Chemotherapy: chemotherapy is one of the common treatments for advanced stage of mixed lung cancer, and the drugs used are cytotoxic drugs, and most of them need to be combined with two kinds of chemotherapeutic drugs at the same time, and the commonly used drugs include paclitaxel, docetaxel, cisplatin, gemcitabine and so on. 2. Targeted drug therapy: according to the results of lung cancer gene examination, corresponding drugs can be selected. For common EGFR mutation, the drugs of choice include gefitinib, ositinib, axitinib, erlotinib and so on. 3. Radiotherapy: Radiotherapy adopts radiation, which is a localized treatment. The radiation dose is calculated according to the size of the site of the lesion and the type of pathology. The prognosis of advanced stage of mixed lung cancer is poor, and it is necessary to formulate a treatment plan after comprehensively evaluating the patient’s condition under the guidance of specialists.