Flu-like symptoms: manifested as fever, chills, headache, muscle aches, and malaise. Transient peripheral thrombocytopenia: mainly manifests as peripheral leukocytopenia and thrombocytopenia. Mental abnormalities: may manifest as depression, delusions, severe anxiety and other psychiatric symptoms. Zhao Wenxia, Department of Spleen, Gastrointestinal, Hepatobiliary Diseases, The First Affiliated Hospital of Henan College of Traditional Chinese Medicine Autoimmune diseases: some patients may develop autoantibodies, and only some patients develop thyroid disease (hyperthyroidism or hypothyroidism), diabetes, thrombocytopenia, psoriasis, leukoplakia, rheumatoid arthritis and systemic lupus erythematosus-like syndrome. Other rare adverse reactions: include renal injury (interstitial nephritis, nephrotic syndrome, acute renal failure), cardiovascular disease (arrhythmia, ischemic heart disease, cardiomyopathy, etc.), retinopathy, hearing loss, or interstitial pneumonia.