Syphilis in pregnancy is defined as a woman with syphilis who is pregnant. This refers to a woman with overt syphilis or latent syphilis who has contracted syphilis during pregnancy, or during pregnancy. However, as long as a pregnant woman has syphilis, it is very harmful to the fetus. The clinical manifestations of syphilis have proved that whether the woman has already had syphilis before pregnancy or has contracted syphilis during pregnancy, she may transmit syphilis to the fetus, especially in early stages of syphilis, so that the fetus has a greater chance of being infected. The spirochetes in the mother’s body during pregnancy can enter the child’s body through the placenta, often resulting in miscarriage, stillbirth or premature birth. Even if the baby is born at full term, it may already be a child with syphilis. This not only directly affects the survival rate of the fetus, but also affects the healthy development of the fetus. Common causes of syphilis flow, death and premature birth of pregnant women are as follows: 1. Miscarriage: mostly occurs in the 4th to 6th month of pregnancy, spirochetes can cause inflammation of small arteries in the placenta, forming arterial infarction, to necrosis of the placental tissue, supplying insufficient nutrition to the fetus and miscarriage occurs. The fetus needs to be excluded from the uterus to benefit the mother. 2. Premature birth: Most of them occur during the 6th to 8th month of pregnancy, i.e., they are delivered early. 95% of them will die shortly after birth. This is because the syphilis spirochete has invaded the internal organs of the fetus, resulting in damage to the organs and inadequate function, and it is extremely difficult for the premature baby to adapt to the external environment after birth, and will die if there is an infection. If there are a few who are spared from death, they are also congenital syphilis children. 3, stillbirth: seen in the pregnancy has reached full term, but when the days before delivery, or the sudden changes that occur at the time of delivery, and the output of stillbirth. Women with syphilis who have not undergone anti-syphilis treatment or incomplete treatment may have surviving babies after 3 to 4 aborted, premature or stillbirths as the disease lengthens. However, 60% of these babies may be infected with syphilis, and only about 40% of the babies are spared from infection and become healthy. We all know that syphilis is a common sexual disease, so pregnant women with syphilis during the treatment of what are the main considerations are as follows: 1, married women with a history of syphilis disease before pregnancy must be a comprehensive syphilis test Men who have had an unclean sex life or have been infected with syphilis before planning to get pregnant, it is best to go to a regular hospital to do a comprehensive syphilis test, for those who have completed treatment of syphilis, syphilis performance is not obvious Married men also need to be sure that the syphilis is completely cured before they can get pregnant. The syphilis test should include the syphilis serological screening test (such as VSR or RPR test), syphilis test and FTAABS or TPHA test, any positive result of which will require the use of drugs such as gonorrhea to continue the syphilis treatment. If a pregnant woman with syphilis still has a positive test result in the third month of pregnancy, she needs to be treated again; if the serological test is positive in the last three months of pregnancy, she needs to be treated completely for syphilis. 2, healthy pregnant women infected with syphilis during pregnancy treatment matters healthy pregnant women who are infected with syphilis during pregnancy, the serological test results may be negative at this time, in the last three months of pregnancy must be given timely anti-syphilis treatment.